The International Skin Imaging Collaboration: Melanoma Project is an academia and industry partnership designed to facilitate the application of digital skin imaging to help reduce melanoma mortality. When recognized and treated in its earliest stages, melanoma is readily curable. Digital images of skin lesions can be used to educate professionals and the public in melanoma recognition as well as directly aid in the diagnosis of melanoma through teledermatology, clinical decision support, and automated diagnosis. Currently, a lack of standards for dermatologic imaging undermines the quality and usefulness of skin lesion imaging. ISIC is developing proposed standards to address the technologies, techniques, and terminology used in skin imaging with special attention to the issues of privacy and interoperability (i.e., the ability to share images across technology and clinical platforms). In addition, ISIC has developed and is expanding an open source public access archive (ISIC Archive) of skin images to test and validate the proposed standards. This archive serves as a public resource of images for teaching and for the development and testing of automated diagnostic systems.